Azelaic Acid
THE MULTITASKER
Calms rosacea-prone skin with visible redness, papules, and pustules — the versatile active that works on redness and bumps at once, at a therapeutic strength.Rosacea · Three-Active Prescription
The Advanced Redness Solution Rx
Azelaic Acid · Ivermectin · Metronidazole
For rosacea that keeps coming back after milder treatments.
$44.50/month
Starting with a 2-month supply
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
Rosacea · Three-Active Prescription
The Advanced Redness Solution Rx
Azelaic Acid · Ivermectin · Metronidazole
For rosacea that keeps coming back after milder treatments.
$44.50/month
Starting with a 2-month supply
Azelaic acid calms the redness and acne-like bumps of rosacea-prone skin. Ivermectin targets Demodex mites, a driver of flare-ups that most rosacea treatments never address. Metronidazole quiets the inflammation behind persistent papules and pustules. Three prescription actives in one nightly formula, for skin where one active stopped being enough.
Treats the following concerns:
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
Formulations
The Advanced Redness Solution Rx is a single standard formulation. Azelaic acid 15% works on the redness and acne-like bumps of rosacea-prone skin. Ivermectin 1% targets Demodex mite activity linked to flare-ups. Metronidazole 1% quiets the inflammation behind papules and pustules. Centella asiatica and ceramides are included to keep a three-active formula comfortable for nightly use.
Active ingredients:
- Azelaic acid 15%
- Ivermectin 1%
- Metronidazole 1%
Supporting ingredients:
- Centella asiatica
- Ceramides
Compounded medications are not FDA-approved.
How & Why It Works
- Azelaic acid works on both the redness and the acne-like bumps of rosacea-prone skin, so it covers two concerns with one active
- Ivermectin targets Demodex mites, which live in the follicle and drive flare-ups in many rosacea-prone faces
- Metronidazole quiets the inflammation behind persistent papules and pustules
- Three actives on three separate drivers, which is why it is built for rosacea that a single active did not hold
- Applied once at night, so it stays on the skin through the hours it is repairing
- Centella asiatica helps keep skin comfortable while the actives work
- Ceramides support the skin barrier so a three-active formula stays tolerable
- Compounded by a licensed pharmacy for each prescription
How to Use
Apply a thin layer to clean, dry skin once daily in the evening. Wait at least 20 minutes after washing and patting dry before you apply it.
Start with every other night for the first 1 to 2 weeks, then move to nightly as your skin tolerates it. Your DermClick care team will adjust your ramp-up based on how your skin responds.
A pea-sized amount covers the whole face. More does not work better and can sting.
Avoid the eyes, lips, the corners of the nose, and any broken or irritated skin.
Follow with a fragrance-free, barrier-supporting moisturizer. In the morning, wear a broad-spectrum sunscreen, minimum SPF 30.
Pause use for at least one week before and after waxing, laser, or chemical peels in the treated area.
- One bottle is approximately a 2-month supply
Pairs Well With
The Redness Control Formula
Daytime visible redness relief that layers over your nightly treatment. The Advanced Redness Solution works on what drives the flare; Redness Control reduces how red your skin looks during the day.
The Clarifying Rosacea Formula
A prescription wash for rosacea-prone skin that gets oily. It does its work in the cleansing step; The Advanced Redness Solution goes on after, at night.
100% Compounded Online PharmacyPrescription-Only TreatmentsNo Long-Term Commitments
What's The Advanced Redness Solution?
Azelaic acid calms the redness and acne-like bumps of rosacea-prone skin. Ivermectin targets Demodex mites, a driver of flare-ups that most rosacea treatments never address. Metronidazole quiets the inflammation behind persistent papules and pustules. Three prescription actives in one nightly formula, for skin where one active stopped being enough.
Treats the following concerns:
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
Formulations
The Advanced Redness Solution Rx is a single standard formulation. Azelaic acid 15% works on the redness and acne-like bumps of rosacea-prone skin. Ivermectin 1% targets Demodex mite activity linked to flare-ups. Metronidazole 1% quiets the inflammation behind papules and pustules. Centella asiatica and ceramides are included to keep a three-active formula comfortable for nightly use.
Active ingredients:
- Azelaic acid 15%
- Ivermectin 1%
- Metronidazole 1%
Supporting ingredients:
- Centella asiatica
- Ceramides
Compounded medications are not FDA-approved.
How & Why It Works
- Azelaic acid works on both the redness and the acne-like bumps of rosacea-prone skin, so it covers two concerns with one active
- Ivermectin targets Demodex mites, which live in the follicle and drive flare-ups in many rosacea-prone faces
- Metronidazole quiets the inflammation behind persistent papules and pustules
- Three actives on three separate drivers, which is why it is built for rosacea that a single active did not hold
- Applied once at night, so it stays on the skin through the hours it is repairing
- Centella asiatica helps keep skin comfortable while the actives work
- Ceramides support the skin barrier so a three-active formula stays tolerable
- Compounded by a licensed pharmacy for each prescription
How to Use
Apply a thin layer to clean, dry skin once daily in the evening. Wait at least 20 minutes after washing and patting dry before you apply it.
Start with every other night for the first 1 to 2 weeks, then move to nightly as your skin tolerates it. Your DermClick care team will adjust your ramp-up based on how your skin responds.
A pea-sized amount covers the whole face. More does not work better and can sting.
Avoid the eyes, lips, the corners of the nose, and any broken or irritated skin.
Follow with a fragrance-free, barrier-supporting moisturizer. In the morning, wear a broad-spectrum sunscreen, minimum SPF 30.
Pause use for at least one week before and after waxing, laser, or chemical peels in the treated area.
- One bottle is approximately a 2-month supply
Pairs Well With
The Redness Control Formula
Daytime visible redness relief that layers over your nightly treatment. The Advanced Redness Solution works on what drives the flare; Redness Control reduces how red your skin looks during the day.
The Clarifying Rosacea Formula
A prescription wash for rosacea-prone skin that gets oily. It does its work in the cleansing step; The Advanced Redness Solution goes on after, at night.
The clinical team
The medicine behind your prescription is built by the doctors you already follow.
The Advanced Redness Solution Rx wasn't formulated by an algorithm or pulled from a generic template. Its protocol was designed by Dr. Lindsey Zubritsky, Dr. Mamina Turegano, and Dr. Jenny Liu — three board-certified dermatologists with decades of combined experience treating real patients.
Your prescription is then written by a board-certified dermatologist on our clinical team, working from the protocol they built. Dermatologist-built medicine, delivered to your door.
Dr. Lindsey Zubritsky MDDr. Mamina Turegano, MDDr. Jenny Liu, MD
What's in the bottle
Real actives. Named, not hidden.
The Advanced Redness Solution Rx stacks three prescription actives with two supporting ingredients — a dermatologist's multi-active protocol, compounded into a single nightly application instead of three separate prescriptions you'd have to layer yourself.
Active Ingredients
Ivermectin
THE MITE DISRUPTOR
Targets the Demodex mite activity linked to rosacea flares, while calming the inflammation those flares produce. The active most people have never heard of — and often the one that changes things.
Metronidazole
THE INFLAMMATION QUIETER
The most prescribed prescription topical for rosacea in clinical practice. An antibiotic and anti-inflammatory that helps reduce the redness and inflammatory lesions rosacea leaves behind.Supporting Ingredients
Centella Asiatica
THE CALMER
A clinically studied botanical that soothes irritation and supports recovery. Used in dermatology for decades — the quiet ingredient that keeps the strong ones comfortable.
Ceramides
THE BARRIER REPAIR
Lipids that reinforce the skin barrier and lock in moisture. For reactive skin, barrier health is what makes treatment tolerable — ceramides protect the foundation.Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.
What to expect
Multi-active control for rosacea that refuses to settle.
The Advanced Redness Solution Rx is built for rosacea that needs multi-active support. Azelaic acid supports redness-prone skin with acne-like papules. Ivermectin addresses Demodex mite activity, a major contributor to chronic flare-ups that most people don't know about. Metronidazole — the most prescribed topical for rosacea in clinical practice — supports visible redness concerns. Centella asiatica supports your barrier so your skin can tolerate the protocol.
- Supports persistent rosacea-prone redness, not just same-day visible symptoms
- Helps reduce the look of flare-prone redness over time
- Supports papules and pustules on rosacea-prone skin
- Helps calm the look of persistent baseline redness
- Combines three prescription actives in one nightly application
Built for the woman whose rosacea won't quit.
The Advanced Redness Solution Rx is our maximum-strength rosacea prescription — three actives working together to address the root drivers of stubborn flare-ups. If you've tried single-active treatments without lasting control, this is the formula designed for that. It's not a starter — it's what a board-certified dermatologist would step you up to when gentler protocols stop holding the line.
Ideal for you if you're
Experiencing frequent or severe rosacea flare-ups
Finding that milder treatments have not provided lasting relief
Dealing with persistent redness alongside inflammatory papules and pustules
Suspecting Demodex involvement (skin that worsens with heat, makeup, or stress)
Ready for a stronger prescription rosacea treatment, as confirmed during your assessment
Consider a different fit if you're:
Pregnant, nursing, or trying to conceive. The Redness & Acne Formulaᴿˣ is built around azelaic acid and can often be continued through pregnancy, confirmed during your assessment
New to prescription rosacea treatment — a board-certified dermatologist on your care team may want to start you on a gentler formula first
Looking for fast same-day visible redness relief — The Redness Control Formulaᴿˣ uses oxymetazoline for daytime symptom control
Already on oral antibiotics for rosacea — your assessment will determine whether the combination is appropriate
Sensitive to topical antibiotics or have a history of antibiotic-resistant skin infections
What our customers are saying.
BeforeAfter
No makeup, no touchups
★★★★★
“My face was red almost every day, and when I flared it would get so much worse. I had tried so many products that would help for a week or two and then I was right back where I started. After a few months with this formula, my skin is so much calmer and my flare-ups are nowhere near as intense. I finally feel like I have some control over my rosacea.”
Hannah
BeforeAfter
No makeup, no touchups
★★★★★
“I always struggled with both the redness and these little inflamed bumps across my cheeks. I honestly couldn't tell if it was acne or rosacea anymore. This is the first treatment I've used where I noticed both improving at the same time. I still get some redness, but compared to where I started, the difference is huge.”
Gabriela
BeforeAfter
No makeup, no touchups
★★★★★
“Rosacea didn't look like the bright red pictures I kept seeing online, so it took me forever to understand what was happening with my skin. Mine looked more like irritated, darker red patches with bumps that kept coming back. My skin is much calmer now and I'm getting far fewer of those painful flare-ups.”
Naomi
BeforeAfter
No makeup, no touchups
★★★★★
“I came to DermClick after years of trying to manage my rosacea. Some things helped temporarily, but nothing seemed to keep it under control. I wasn't expecting an overnight change, but after staying consistent I realized I was going longer and longer without a major flare. My skin isn't perfect, but it's dramatically better than where I started.”
Caroline
BeforeAfter
No makeup, no touchups
★★★★★
“The worst part for me was how unpredictable my skin was. I could wake up with my cheeks hot, irritated and covered in bumps even when I hadn't changed anything in my routine. The difference now is incredible. My skin looks calmer, the bumps have reduced so much, and even when I do flare it doesn't seem to take over my whole face.”
Keisha
BeforeAfter
No makeup, no touchups
★★★★★
“My skin had become so reactive that I was scared to try anything new. My cheeks and nose were constantly flushed and almost everything seemed to make them feel irritated. I was very cautious starting treatment, but I'm so glad I did. A few months later, my baseline redness is noticeably lower and my skin doesn't feel like it's constantly on the verge of another flare.”
Mei
Realistic timeline
What you may see in 6–12 weeks.
Multi-active rosacea treatment works gradually but more comprehensively than single-active protocols. Here's what most people experience with consistent nightly use.
Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
Weeks 1–2
Adjustment
Your skin gets used to a higher-strength prescription. Tingling, mild dryness, or temporary flushing is common as the actives ramp up. Your dermatology care team can adjust frequency if it's too much. Some people see a brief worsening in the first 1 to 2 weeks as Demodex mites decline. It settles on its own.Weeks 3–6
Calming
Papules and pustules begin to look calmer. Visible redness may soften. You may notice fewer flare-ups in response to your usual triggers. This is the point most people feel the formula working.Weeks 6–12
Visible improvement
Persistent baseline redness looks meaningfully reduced. Flares are less frequent and less intense. Your skin starts to feel like it's no longer fighting itself.Beyond 12 weeks
Maintenance and adjustment
Your dermatology care team checks in. Some people can be stepped down to a maintenance formula. Others stay on the full protocol. Rosacea is chronic — ongoing care is how the gains hold.Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
How DermClick works
Three steps. No appointments. Reviewed by a board-certified dermatologist within one business day.
Tell us about your skin.
Take our skin assessment. Share your concerns, your skin's history, what you've tried before, and a few photos. The more we know, the better the formula.
One business day review
Your case is reviewed within one business day, and your prescription is written by a board-certified dermatologist on our clinical team.
Azelaic Acid
Ivermectin
MetronidazoleYour prescription arrives
Your formula is compounded by a licensed pharmacy and shipped to your door — usually within a week. Your dermatologist stays with you, adjusting your formula as your skin responds.
Frequently Asked Questions
Should I start with a gentler rosacea formula or go straight to The Advanced Redness Solutionᴿˣ?
If you're new to prescription rosacea care, a board-certified dermatologist on your care team may recommend starting with The Redness & Acne Formulaᴿˣ — a gentler daily formula built around azelaic acid. The Advanced Redness Solutionᴿˣ is our maximum-strength tier, built for rosacea-prone skin with frequent flare-ups, persistent papules and pustules, and redness that milder protocols haven't supported enough. If you're not sure which tier fits, take the assessment. A board-certified dermatologist on your care team will tell you which one matches where your skin actually is.
What is ivermectin doing in a rosacea formula?
Ivermectin is included for skin patterns where Demodex mite activity may be part of the rosacea-prone picture. Demodex are microscopic organisms that live on the skin and are found in higher concentrations in many rosacea people. Adding ivermectin gives the formula another mechanism for papules, pustules, and flare-prone redness beyond azelaic acid and metronidazole alone.
Can I use this with my current skincare routine, or do I have to start over?
Most gentle routines can stay. Gentle cleansers, hydrating serums, broad-spectrum SPF, and barrier-supporting moisturizers pair well with The Advanced Redness Solutionᴿˣ. A board-certified dermatologist on your care team will tell you what to pause — including duplicate retinoids, topical antibiotics that might conflict, strong exfoliants, or physical scrubs — during your assessment.
What are the side effects and safety information for The Advanced Redness Solutionᴿˣ?
The most common effects are mild tingling, dryness, or flaking in the first 2 to 4 weeks as your skin adjusts, and some people notice a brief worsening in the first 1 to 2 weeks as Demodex mites decline. It should not be used during pregnancy or while nursing, within two weeks of disulfiram (Antabuse), or within six months of oral isotretinoin. Alcohol can rarely cause a flushing reaction with metronidazole. The full list of warnings, interactions, and what to do if you have a reaction is in the Important Safety Information. A board-certified dermatologist on our clinical team reviews your medical history during your assessment before it is prescribed.
Read the full Important Safety Information →Is The Advanced Redness Solutionᴿˣ safe with pregnancy, nursing, or other medications?
The assessment asks about this specifically. If pregnancy, nursing, trying to conceive, or medication conflicts apply, a board-certified dermatologist on your care team will route you to a safer option or tell you if treatment is not appropriate before charging you.
When will I see results?
Most people notice a meaningful shift between weeks 6 and 12 with consistent nightly use. Multi-active rosacea care works gradually and is selected for broader skin patterns than single-active protocols. Weeks 1–2 are the adjustment period. Weeks 3–6, papules and pustules may look calmer and flares may become less frequent. Weeks 6–12, persistent baseline redness can look meaningfully reduced. Your DermClick care team can adjust your formula if your skin is moving slower than expected.
What type of skin is The Advanced Redness Solutionᴿˣ designed for?
It's designed for adult rosacea-prone skin with moderate to severe presentation — persistent facial redness, frequent flare-prone reactivity, papules and pustules that return despite care, and skin that may have Demodex involvement. It's not the right starting point for someone new to prescription rosacea care — The Redness & Acne Formulaᴿˣ is built for that, and the assessment routes you clearly between them.
The Advanced Redness Solution Rx handles the underlying drivers of persistent rosacea. If you also need daytime symptom control, or if you're earlier in your rosacea journey and want a gentler starting point, there's a formula for that too.
